News
2024
- Cheng joined the School of Public Health at Sun Yat-sen University as an Associate Professor.
Before 2024
- To be updated...
Research
Our research revolves around creating new methods for discovering pathogens and conducting diagnostic studies. By applying these innovative methods, we want to rapidly detect potential pathogenic microorganisms in both clinical and zoonotic settings, and also to investigate the potential mechanisms behind unexplained illnesses, such as, ME/CFS and the post-acute infection syndromes.
- Our previous work includes pioneering the field of pathogen capture sequencing technology and high-throughput Serochip technology. We have developed BacCapSeq, a groundbreaking platform capable of simultaneously screening for all human pathogenic bacteria, as well as virulence and antibiotic resistance markers.
- We were the first to discover that SARS-CoV-2 viral RNA can persist in patients' digestive tracts even months after its elimination from their respiratory tracts.
- We have also conducted molecular epidemiological studies on numerous studies, aiming to enhance public health policies and raise awareness of the One Health concept.
- Furthermore, our research has demonstrated that intestinal bacteria can serve as biomarkers for diagnosing Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). This finding opens up possibilities for potential treatment therapies by analyzing the association between microorganisms and ME/CFS.
To date, our efforts have resulted in 50+ SCI papers with 3300+ citations.
1. Pathogen Discovery: emerging and re-emerging infectious diseases
2. One Health: prevent the next pandemic
3. Microbiome: human microbiome and diseases associated with infection
People
Cheng Guo, PhD, Associate Professor
guoch36@mail.sysu.edu.cn • Google Scholar • Twitter • LinkedIn
guoch36@mail.sysu.edu.cn • Google Scholar • Twitter • LinkedIn
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2024- Senior consultant for CII at Columbia University
2022-2023 Head of bioinformatics team for CII at Columbia University
2016-2023 Senior programmer analyst for CII at Columbia University
2015-2016 Bioinformatician for U.S. Environmental Protection Agency
2011-2016 Ph.D student at Miami University
2004-2008 Bachelor & 2008-2011 Master student at China Pharmaceutical University
lab members
Dudu
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Naive newborn
Dudu says: "认真工作，痛快玩耍,欢迎各位加入大家庭!"
Academic Service
- Editor board member for Journal of Urology and Renal Diseases
- Editor board member for Clinical Pathology and Research Journal
- Editor for Journal One Health Bulletin
- Guest Editor for Frontiers in Plant Science (Computational Methods in Inferring Cancer Tissue-of-Origin and Cancer Molecular Classification)
- Guest Editor for Frontiers in Genetics (Computational Methods in Inferring Cancer Tissue-of-Origin and Cancer Molecular Classification)
- Guest Editor for Frontiers in Oncology (Cancer Imaging and Image-directed Interventions)
Resources
- PubMed: NCBI PubMed database.
- bioRENDER: Images and clip art for biology.
- Microbe TV: Great podcast resource for microbes.
Selected Publications
2024
2023
- Deficient butyrate-producing capacity in the gut microbiome is associated with bacterial network disturbances and fatigue symptoms in ME/CFS. Cell Host and Microbe
- The microbiome in post-acute infection syndrome (PAIS). Computational and Structural Biotechnology Journal
- A meta-transcriptomic study of mosquito virome and blood feeding patterns at the human-animal-environment interface in Guangdong Province, China. One Health
Before 2023
- Characteristics of post-Wuhan COVID-19 outbreaks in mainland China. One Health Bulletin
- Meta-analysis of 16S rRNA microbial data identified alterations of the gut microbiota in COVID-19 patients during the acute and recovery phases BMC microbiology
- Genomic characterization of Wenzhou mammarenavirus detected in wild rodents in Guangzhou City, China. One Health
- Pre-Existing Cross-Reactive Antibody Responses Do Not Significantly Impact Inactivated COVID-19 Vaccine-Induced Neutralization. Frontiers in Immunology
- Altered oral and gut microbiota and its association with SARS-CoV-2 viral load in COVID-19 patients during hospitalization. npj Biofilms and Microbiomes
- A comparative study of associated microbiota between pig farm and pig slaughterhouse in Guangdong, China. Current Microbiology
- Prolonged presence of SARS-CoV-2 viral RNA in faecal samples. The lancet Gastroenterology & hepatology
- BacCapSeq: a platform for diagnosis and characterization of bacterial infections. mBio
- Genome-Wide Comparative Analysis of Miniature Inverted Repeat Transposable Elements in 19 Arabidopsis thaliana Ecotype Accessions. Scientific reports
- RNAi-mediated transgenic rice resistance to Rice stripe virus. Journal of Integrative Agriculture
- A Genome-wide Study of “Non-3UTR” Polyadenylation Sites in Arabidopsis thaliana. Scientific reports
- Alterations in siRNA and miRNA expression profiles detected by deep sequencing of transgenic rice with siRNA-mediated viral resistance. PLoS One